Not known Facts About mif

MIF and host responses to other pathogens. Together with bacterial sepsis, MIF has been implicated from the pathogenesis of parasitic (malaria, cysticercosis and leishmaniasis) and viral (cytomegalovirus and influenza virus) bacterial infections. MIF is produced from the lymph nodes of mice contaminated with Leishmania key, and in more info vivo administration of recombinant MIF lowered the severity of infection67. Mice that lack Mif had been a lot more susceptible to leishmaniasis and cysticercosis than wild-kind mice68,sixty nine.

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Though MIF was discovered as an element that is produced by activated lymphocytes, to date minor is understood about its purpose in adaptive immunity. T cells constitutively express MIF73. Mitogens, tetanus toxoid, CD3-unique antibody, TSST1 and glucocorticoids are actually claimed to promote the discharge of MIF from T cells or from mouse splenocytes66,73,82. Though MIF is mainly considered made by TH2 cells73, It's also produced by TH0 and TH1 cells (T.

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